What is Zoloft?

Zoloft is the trade name for Sertraline Hydrochloride. Zoloft is an antidepressant in a class of drugs called selective serotonin reuptake inhibitors (SSRIs).

Sertraline is primarily used to treat depression, obsessive-compulsive disorder, anxiety disorders, panic disorder, premenstrual dysphoric disorder (PMDD) and post-traumatic stress disorder (PTSD).

Zoloft can also be used for other purposes than those listed here.

Zoloft oral administration is available as scored tablets wich contain sertraline hydrochloride equivalent to 25, 50 and 100 mg of sertraline. Bottles of Zoloft are sold in the United States, with blue (50 mg) and green (25 mg) tablets.

Zoloft is also available as oral concentrate solution, in a multidose 60 mL bottle, each mL of solution containing sertraline hydrochloride equivalent to 20 mg of sertraline.

Zoloft was introduced to the U.S. market by Pfizer in 1991, to the Australian market in 1994 and became the most often prescribed antidepressant in 1996.

In 2005, the Food and Drug Administration (FDA) added a black box warning regarding pediatric suicidality to all antidepressants, including sertraline.

In 2006, the U.S. patent for Zoloft expired, and sertraline is now available in generic form.

In 2007, Zoloft was the most prescribed antidepressant on the U.S. retail market, with a number of 29,652,000 prescriptions.


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